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Search Result "HepaRG"

Research Article

Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells

Journal: Drug Metabolism Letters
Volume: 12 Issue: 1 Year: 2018 Page: 14-23
Author(s): Akira Ogasawara,Nozomu Kato,Nao Torimoto,Fumika Aohara,Rikiya Ohashi,Yasuhiro Yamada,Hideki Taniguchi

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

Journal: Drug Metabolism Letters
Volume: 9 Issue: 1 Year: 2015 Page: 3-7
Author(s): Norie Murayama,Takashi Usui,Nicky Slawny,Christophe Chesne,Hiroshi Yamazaki

Research Article

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

Journal: Current Pharmaceutical Biotechnology
Volume: 18 Issue: 1 Year: 2017 Page: 806-814
Author(s): Camille Richeval,Thomas Gicquel,Chloe Hugbart,Brendan Le Dare,Delphine Allorge,Isabelle Morel,Jean-michel Gaulier

The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches

Journal: Current Drug Metabolism
Volume: 11 Issue: 1 Year: 2010 Page: 870-885
Author(s): Ken Grime, Douglas D. Ferguson, Robert J. Riley

Research Article

New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery

Journal: Drug Metabolism Letters
Volume: 10 Issue: 3 Year: 2016 Page: 152-160
Author(s): Akira Ogasawara, Nao Torimoto, Naoki Tsuda, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada, Hideki Taniguchi

In vitro Toxicity Evaluation and in vivo Biodistribution of Polymeric Micelles Derived from Poly(ethylene glycol)-b-poly(benzyl malate) Copolymers

Journal: Pharmaceutical Nanotechnology
Volume: 4 Issue: 1 Year: 2016 Page: 24-37
Author(s): Elise Vene,Kathleen Jarnouen,Zhi Wei Huang,Bedhouche Wahib,Tristan Montier,Sandrine Cammas-Marion,Pascal Loyer

Research Article

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

Journal: Drug Metabolism Letters
Volume: 13 Issue: 1 Year: 2019 Page: 45-52
Author(s): Andrey A. Poloznikov,Sergey V. Nikulin,Arpenik A. Zakhariants,Anna Y. Khristichenko,Dmitry M. Hushpulian,Ildar N. Gazizov,Vladimir I. Tishkov,Irina G. Gazaryan

Research Article

Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model

Journal: Drug Metabolism and Bioanalysis Letters
Volume: 15 Issue: 0 Year: 2022 Page: 1-6
Author(s): Yusuke Kamiya,Tomonori Miura,Airi Kato,Norie Murayama,Makiko Shimizu,Hiroshi Yamazaki

3D Hepatic In Vitro Models as Tools for Toxicity Studies

Journal: Current Tissue Engineering
Volume: 2 Issue: 1 Year: 2013 Page: 78-89
Author(s): D. Mueller, E. Heinzle, F. Noor

Reactive Metabolites in Early Drug Development: Predictive In vitro Tools

Journal: Current Medicinal Chemistry
Volume: 22 Issue: 4 Year: 2015 Page: 538-550
Author(s): Olavi Pelkonen, Markku Pasanen, Ari Tolonen, Mikko Koskinen, Jukka Hakkola, Khaled Abass, Jaana Laine, Merja Hakkinen, Risto Juvonen, Seppo Auriola, Markus Storvik, Pasi Huuskonen, Timo Rousu, Maiju Rahikkala

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